STUDY - Direct Smartphone Exposure Triggers Rapid Red Blood Cell Aggregation
Ultrasound imaging reveals potential cardiovascular risks from prolonged smartphone contact with the body.
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Nicolas Hulscher MPH 2025.04.01
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Nicolas Hulscher MPH
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Nicolas Hulscher, MPH
The study titled, Hypothesis: ultrasonography can document dynamic in vivo rouleaux formation due to mobile phone exposure, was recently published in Frontiers in Cardiovascular Medicine:
Carrying a cellphone against the body has become commonplace in our world replete with smartphones. Acute and chronic health effects caused by these devices emitting radiofrequency radiation from multiple antennas have not been well evaluated.
In this study, the popliteal vein of a healthy volunteer was imaged with ultrasonography prior to and following the placement of an idle, but active smartphone against her knee for 5 min [Apple iPhone XR smartphone operating on the AT&T mobile network—Wi-Fi, Bluetooth, and cellular data antennas were all turned on, but the phone was otherwise inactive and idle.].
Pre-exposure longitudinal sonographic images demonstrate a normal anechoic lumen to the popliteal vein. Images obtained 5 min after direct skin exposure to the smartphone demonstrate a dramatic change in the acoustic appearance of the vessel. The interior of the vessel became coarsely hypoechoic with sluggish flow seen in real-time images, a typical sonographic appearance for rouleaux formation. A follow up examination performed 5 min after the subject walked around yielded continued rouleaux formation in the popliteal vein, albeit less dramatic than that observed immediately post exposure. This revolutionary in vivo method to assess radiofrequency radiation induced rouleaux formation should be further pursued in the general population to determine its prevalence and if its occurrence provides a unique biomarker of exposure that may predict morbidity.
To illustrate this study in an easy-to-understand diagram, I created the following graphic:
This study raises serious safety concerns about prolonged, direct exposure to smartphones. As the authors note:
Because tissue perfusion is inversely proportional to blood viscosity, the potential development of rouleaux formation from cellphone exposure is of great concern. Rouleaux formation creates a hypercoagulable state, and may impair oxygen delivery, contributing to tissue ischemia. If the red blood cell aggregation response is indeed systemic, it may have wide reaching multi-systemic effects, including the development or exacerbation of hypertension (10). Morbidity is determined by the patient's underlying health status. Ischemic heart disease, diabetes, prethrombotic states, cancer, peripheral vascular disease, retinopathy, and cerebrovascular insufficiency are among the risk factors that will increase the morbidity associated with the development of rouleaux (11). Although rouleaux is a transient phenomenon, the frequent use of cellphones throughout the day, and potentially other technology commonly found in today's society, may repetitively increase blood viscosity and contribute to micro-occlusions, micro-infarctions, and micro-gangrene. Excessive aggregation of erythrocytes can increase one's susceptibility to develop acute infections, myocardial infarction, and increase one's the risk for deep venous thrombosis (12).
Coin Stacking of Red Blood Cells - Rouleaux Formation
It’s entirely possible that this phenomenon could also occur in other areas of the body—particularly when a phone is kept in a pants pocket for extended periods or held next to the head during a call.
Urgent further investigation is needed to replicate these findings with larger sample sizes and to assess their relevance to other areas of the body. If you are at high risk for cardiovascular events, it may be wise to avoid direct, prolonged contact with your smartphone until these concerns are thoroughly evaluated.
All potential biological harms from smartphones and their emitted EMFs should have been thoroughly studied decades ago—before mass deployment. Unfortunately, the current trend in the cellular industry reflects a dangerous assumption: "Assumed Safe, Not Proven Safe."
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Nicolas Hulscher, MPH
Epidemiologist and Foundation Administrator, McCullough Foundation
www.mcculloughfnd.org |